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apalutamide will decrease the level or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in reduce exposure to these prescription drugs.Don't drink alcohol while taking diazepam.